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InChiKey: QLUWQAFDTNAYPN-LLVKDONJSA-N
robust PK/PD correlation and tumor growth inhibition (TGI) in a U87MG mouse xenograft model
InChiKey: BJFSUDWKXGMUKA-UHFFFAOYSA-N
triggering rapid accumulation of polyubiquitinated proteins
CVT-10216 - CAS# 1005334-57-5 Catalog No.:M6674-2 InChiKey: QLUWQAFDTNAYPN-LLVKDONJSA-NCVT 10216, CAS No. 1005334 57 5, is a Potent and selective, reversible inhibitor of aldehyde dehydrogenase 2 (ALDH2) (IC50 values are 29 and 1300 nM for ALDH2 and ALDH1, respectively). CVT 10216 increases acetaldehyde after alcohol gavage and inhibits 2 bottle choice alcohol intake in heavy drinking rodents, including deprivation induced drinking. Moreover, CVT 10216 also prevents operant self administration and eliminates cue induced reinstatement of
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