RepSox - TGF-β Type I Receptor ALK5 Inhibitor. CAS# 446859-33-2 0273 At tolerated doses

At tolerated doses

CTEP was used at 0

InChiKey: NEXGBSJERNQRSV-UHFFFAOYSA-N

GSK3235025

RepSox - TGF-β Type I Receptor ALK5 Inhibitor. CAS# 446859-33-2 0273 At tolerated dosesRepSox (E 616452 or SJN 2511), CAS No. 446859 33 2, is a highly potent, selective inhibitor of the TGF type I receptor ALK5 with IC50 of 23 nM and 4 nM for ATP binding to ALK5 and ALK5 autophosphorylation, respectively. It has good selectivity for ALK5 over a range of kinases, including p38 MAPK, JNK1 and GSK3 (IC50 > 16 M). RepSox is able to successfully replace Sox2 in reprogramming by inhibiting transforming growth factor (Tgf ) signaling, which in