LY294002 - PI3K/BET Dual Inhibitor. CAS# 154447-36-6 042 selective and cell-active allosteric inhibitor

selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3)

thus promoting LRP6 phosphorylation and Wnt signaling transduction

InChiKey: UJLAWZDWDVHWOW-YPMHNXCESA-N

PFI-1 was used at 10 µM final concentration in various in vitro assays

LY294002 - PI3K/BET Dual Inhibitor. CAS# 154447-36-6 042 selective and cell-active allosteric inhibitorLY294002, CAS No. 154447 36 6, is a potent and selective small molecule PI3K inhibitor, inhibits PI3K with IC50 of 0. 5 M, 0. 57 M and 0. 97 M, respectively. It is the most widely used PI3K inhibitor to study the role of phosphoinositide 3 kinases in the signal transduction pathways involved in cell migration, proliferation, survival, and metabolism. LY294002 inactivates Akt PKB, consequently inhibiting cell proliferation and inducing apoptosis. It is