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PubMed PMID: 23244871
Long-term daily Conduritol B epoxide treatment of 4L mice (100 mg/kg/day of Conduritol B epoxide from postnatal day 15 for 24 or 36 doses) leads to hind limb paralysis and small amounts of α-synuclein accumulation in the olfactory bulb
InChi: InChI=1S/C19H22O4/c1-12(2)9-10-22-15-7-5-14(6-8-15)17-16(11-13(3)4)18(20)23-19(17)21/h5-9
11(5):524-34
SR-717 lithium - CAS# 2375421-09-1 60295 PubMed PMID: 23244871SR 717 lithium, CAS No. 2375421 09 1, is an agonist of stimulator of interferon genes STING for treating cancer. SR 717 demonstrates broad interspecies and interallelic specificity. SR 717 functions as a direct cyclic guanosine monophosphate adenosine monophosphate (cGAMP) mimetic that induces the same "closed" conformation of STING. SR 717 displayed antitumor activity; promoted the activation of CD8+ T, natural killer, and dendritic cells in relevant
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