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is a potent and selective inhibitor of NUAK1 (IC50 = 100 nM) and does not affect the activity of a panel of 139 other kinases
HMGA2 (high-mobility group AT-hook 2)
Blaquiere N
Dual Inhibition of Activin/Nodal/TGF-β and BMP Signaling Pathways by SB431542 and Dorsomorphin Induces Neuronal Differentiation of Human Adipose Derived Stem Cells
APTO-253 eptor Agonist is a potent and selectiveAPTO 253 (LOR 253, LT 253) inhibits c Myc expression and selectively induces CDKN1A (p21), promotes G0 G1 cell cycle arrest, and triggers apoptosis in acute myeloid leukemia (AML) cells. APTO 253 is also an inducer of KLF4 (Krppel like factor 4). Product information CAS Number: 916151 99 0 Molecular Weight: 367. 38 Formula: C22H14FN5 Chemical Name: 2 (5 fluoro 2 methyl 1H indol 3 yl) 1H imidazo[4,5 f][1,10]phenanthroline Smiles:
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