AZD-1480 - CAS# 935666-88-9 321 It can also cause a

It can also cause a reduction in Aβ40 and Aβ42 levels in human primary neuronal cells (IC50 ~115 nM for total Aβ and ~200 nM for Aβ42) and in brain extracts

Molecular Weight: 507

A randomized

Curr Med Res Opin

AZD-1480 - CAS# 935666-88-9 321 It can also cause aAZD1480. CAS# 935666 88 9, is an orally bioavailable inhibitor of Janus associated kinase 2 (JAK2) with potential antineoplastic activity. JAK2 inhibitor AZD1480 inhibits JAK2 activation, leading to the inhibition of the JAK STAT (signal transducer and activator of transcription) signaling including activation of STAT3. This may lead to induction of tumor cell apoptosis and a decrease in cellular proliferation. JAK2, often upregulated or mutated in a