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The oxocarbazate caused a time-dependent 17-fold drop in IC50 from 6
CAS Number: 874101-00-5
PubMed PMID: 26993765
Formula: C16H14O6
Regorafenib Catalog No.:M10913-10 The oxocarbazate caused a time-dependentRegorafenib, also known as BAY 73 4506 ; is a n orally bioavailable small molecule with potential antiangiogenic and antineoplastic activities. Regorafenib binds to and inhibits vascular endothelial growth factor receptors (VEGFRs) 2 and 3, and Ret, Kit, PDGFR and Raf kinases, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation. Regorafenib demonstrated to increase the overall survival of patients with metastatic