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62-40)33(30)57-24(4)47/h9-15
InChiKey: WWYNJERNGUHSAO-XZCODKSBSA-N
78 nM and 18
AD80 is a polypharmacological agent with an optimal balance of activity against Ret
YS-121 AC for CDK6 62-40)33(30)57-24(4)47/h9-15YS 121 is a dual inhibitor of Microsomal prostaglandin E2 synthase 1 (mPGES 1) . Cyclooxygenases (COX 1 and COX 2) have been involved in catalyzing the formation of prostaglandins and related eicosanoids and play an essential role in the pathogenesis of breast cancer. Actions of COX 2 are mediated by prostaglandin E2 (PGE2). Microsomal PGES 1 (mPGES 1), the inducible form of PGES, has a marked affinity for coupling with COX 2. Expression of mPGES 1
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