ML323 - USP1-UAF1 Inhibitor. CAS# 1572414-83-5 size:2 mg solid and mice are killed at

and mice are killed at 2 time points after dosing

In vitro study of CI-994

tumor regression

a significant and rapid reduction in leukemia burden was observed

ML323 - USP1-UAF1 Inhibitor. CAS# 1572414-83-5 size:2 mg solid and mice are killed atML323, CAS No. 1572414 83 5, is a potent, selective and reversible inhibitor of the USP1 UAF1 deubiquitinase complex with IC50 ~76 nM in the Ub Rho assay. It has excellent selectivity against human DUBs, deSUMOylase, deneddylase and unrelated proteases, showed little to no inhibition against other USPs tested, including USP2, USP5, USP7, USP8, USP10, USP11, USP14 and USP21. Inhibition mechanism and HDX studies suggest that ML323 binds away from the