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the structurally similar but ineffective JAK1/2 inhibitors INCB027753 and INCB029843 has no significant effect in any of these assays systems when tested at concentrations up to 10 μM
IC50 value:Target: P2X2/3 receptor It is known that P2X3 and P2X2/3 receptors stimulate the pronociceptive effects of ATP upon activation
Formula: C74H100ClN17O18
Computer-based identification of a novel LIMK1/2 inhibitor that synergizes with salirasib to destabilize the actin cytoskeleton
MK-0941 odiene the structurally similar but ineffectiveMK 0941 is a potent, orally active and allosteric glucokinase activator, with EC50s of 240 and 65 nM for recombinant human glucokinase in the presence of 2. 5 and 10 mM glucose, respectively. MK 0941 has potential in the treatment of type 2 diabetes. Product information CAS Number: 1137916 97 2 Molecular Weight: 556. 61 Formula: C22H28N4O9S2 Chemical Name: 3 {[6 (ethanesulfonyl)pyridin 3 yl]oxy} 5 {[(2S) 1 hydroxypropan 2 yl]oxy} N (1 methyl 1H