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PubMed PMID: 24900311
InChi: InChI=1S/C19H20N2O3/c1-19(2
ABT-333 (Dasabuvir) is at least 7
1239908-20-3
Palbociclib 1150 PubMed PMID: 24900311Palbociclib, also known as PD 0332991, is an orally available cyclin dependent kinase (CDK) inhibitor with potential antineoplastic activity. Palbociclib selectively inhibits cyclin dependent kinase 4 (CDK4) and 6 (CDK6), thereby inhibiting retinoblastoma (Rb) protein phosphorylation early in the G1 phase leading to cell cycle arrest. This suppresses DNA replication and decreases tumor cell proliferation. CDK4 and 6 are serine threonine kinases that