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Do you really care if your Archon of Cruelty or Etali, Primal Conqueror lose some power when you get those busted abilities two more times

Each player must decide for themselves how often they expect a given ability to be relevant to the game, and whether that upside is worth risking the moments when the card is stuck in your hand

As discussed above, making multiple spider tokens is one of the ways you can do this, but there are some other things you can do

One playthrough is unlikely to provide the strength youll need to survive all the dangers Slay the Spire will throw your way, which is why death is inevitable