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and shows IC50s of >300 μM and 132 μM for human mitochondrial LeuRS and human cytoplasmic LeuRS
1-2H3/t18-/m0/s1
InChiKey: VWNXEDLLHIFAOL-YOVDOAOFSA-N
CI-1033 alone
A-935142 17037 and shows IC50s of >300A 935142 is a human ether a go go related gene (hERG, Kv 11. 1) channel activator. A 935142 enhances hERG current in a complex manner by facilitation of activation, reduction of inactivation, and slowing of deactivation, and abbreviates atrial and ventricular repolarization. Product information CAS Number: 1031335 85 9 Molecular Weight: 352. 35 Formula: C18H19F3N2O2 Chemical Name: 2 (4 {4 [5 (trifluoromethyl) 1H pyrazol 3 yl]phenyl}cyclohexyl)acetic